Primary Certification in General Surgery Exam Prep
Free practice questions

Free General Surgery Practice Questions

10 exam-style questions with answers and explanations, straight from our 1,030-question bank. Tap an answer to check yourself. When you're ready, take the scored version in the free practice test.

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The General Surgery exam has 200 questions and runs 4 hours 30 minutes.

These 10 free General Surgery questions are organized by exam domain, so you can see how each part of the Primary Certification in General Surgery blueprint is tested. Reveal the answer and explanation under each question.

Domain 1: Abdominal 17% of exam

Question 1

A 48-year-old woman is admitted with recurrent right upper-quadrant pain. She is afebrile and hemodynamically stable; her leukocyte count and lipase are normal. Total bilirubin is 3.4 mg/dL and alkaline phosphatase is 286 U/L. Ultrasonography shows gallbladder stones and a 9-mm common bile duct, but no duct stone or gallbladder-wall inflammation. Her pain improves with analgesia. Which investigation should precede a decision about endoscopic duct clearance?

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Correct answer: C - MRCP of the bile ducts

Question 2

Six weeks after an episode of necrotizing pancreatitis, a patient undergoes MRI for persistent early satiety. An 8-cm collection has a complete enhancing capsule and contains both liquid and substantial nonenhancing solid debris. The radiology report calls it a pseudocyst. Under the Revised Atlanta classification, what is the more accurate diagnosis?

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Correct answer: A - Walled-off necrosis

Domain 2: Alimentary Tract 19% of exam

Question 3

Endoscopy for recurrent hematemesis identifies a deep ulcer on the posterior wall of the duodenal bulb. Brisk arterial bleeding resumes despite endoscopic hemostasis, and the interventional radiologist is asked to plan embolization. Which artery lies immediately behind this ulcer and is the principal suspected source?

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Correct answer: B - Gastroduodenal artery

Domain 4: Breast 9% of exam

Question 4

Lumpectomy for a unifocal, 1.7-cm invasive lobular carcinoma leaves a single close margin: tumor is 0.6 mm from the lateral inked surface but does not touch ink. All other margins exceed 4 mm, sentinel nodes are negative, and imaging and pathology account for the entire lesion. There is no associated DCIS. Whole-breast irradiation and endocrine therapy are planned. What should the surgeon recommend about the lateral margin?

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Correct answer: A - No further breast excision

Domain 5: Endocrine 3% of exam

Question 5

Evaluation of a thyroid nodule establishes medullary thyroid carcinoma in a 41-year-old woman with a pathogenic RET variant. She also reports episodic headache and palpitations. Plasma free metanephrines are six times the upper limit of normal, and CT shows a unilateral adrenal mass. There is no airway compression or other urgent thyroid complication. Which treatment sequence avoids the most important preventable operative hazard?

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Correct answer: D - Alpha blockade, then adrenalectomy before thyroidectomy

Domain 15: Pediatric Surgery 3% of exam

Question 6

A 6-week-old boy with ultrasound-confirmed pyloric stenosis has had several days of forceful nonbilious vomiting. He is dehydrated, with sodium 134 mEq/L, potassium 2.8 mEq/L, chloride 86 mEq/L, bicarbonate 38 mEq/L, and arterial pH 7.51. His urine pH is 5.0. What accounts for acidic urine despite the systemic alkalosis?

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Correct answer: A - Sodium conservation with increased renal hydrogen secretion

Domain 17: Pre-operative Evaluation and Peri-operative Care 3% of exam

Question 7

On postoperative day 2 after a right colectomy, a woman with type 2 diabetes develops nausea and deep, rapid breathing. She took empagliflozin until the evening before surgery. Blood pressure is 118/72 mm Hg, lactate 1.2 mmol/L, glucose 164 mg/dL, bicarbonate 11 mEq/L, anion gap 25 mEq/L, and beta-hydroxybutyrate 6.8 mmol/L. She had eaten normally until the preoperative fast. Which diagnosis unifies the medication exposure and laboratory findings?

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Correct answer: D - SGLT2 inhibitor-associated euglycemic ketoacidosis

Domain 18: Skin and Soft Tissue 4% of exam

Question 8

An excisional biopsy of a pigmented lesion on the upper back shows a nonulcerated melanoma with a Breslow thickness of 2.4 mm. The diagnostic biopsy margins are clear. A healthy 52-year-old patient has no palpable regional adenopathy or evidence of distant disease. Which operation provides the appropriate definitive local treatment and regional nodal staging?

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Correct answer: C - Wide excision with a 2-cm margin and sentinel-node biopsy

Domain 19: Surgical Critical Care 3% of exam

Question 9

A man with postoperative pneumonia develops ARDS and is passively ventilated. His actual weight is 120 kg and his height-derived predicted body weight is 70 kg. Current settings include a tidal volume of 700 mL and PEEP of 8 cm H2O. Plateau pressure is 34 cm H2O; arterial pH is 7.29 and PaCO2 is 53 mm Hg. Which tidal-volume adjustment best addresses the immediate risk of ventilator-induced lung injury?

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Correct answer: B - Reduce to 420 mL based on predicted body weight

Domain 23: Trauma 8% of exam

Question 10

After a high-speed collision, a 29-year-old man has a patent airway, symmetric breath sounds, and no major external bleeding. His blood pressure rises from 76/42 to 112/68 mm Hg during transfusion of two units of whole blood, then falls to 82/46 mm Hg within minutes. FAST shows free fluid in the right upper quadrant and pelvis. The abdomen is increasingly distended. While blood-product resuscitation continues, where should he go next?

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Correct answer: D - The operating room for exploratory laparotomy

The rest of the General Surgery blueprint

The General Surgery exam also covers these domains. Drill them in the full free practice test:

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